Design and prototype of a train-to-wayside communication architecture

Telecommunication has become very important in modern society and seems to be almost omnipresent, making daily life easier, more pleasant and connecting people everywhere. It does not only connect people, but also machines, enhancing the efficiency of automated tasks and monitoring automated processes. In this context the IBBT (Interdisciplinary Institute for BroadBand Technology) project TRACK (TRain Applications over an advanced Communication networK), sets the definition and prototyping of an end-to-end train-to-wayside communication architecture as one of the main research goals. The architecture provides networking capabilities for train monitoring, personnel applications and passenger Internet services. In the context of the project a prototype framework was developed to give a complete functioning demonstrator. Every aspect: tunneling and mobility, performance enhancements, and priority and quality of service were taken into consideration. In contrast to other research in this area, which has given mostly high-level overviews, TRACK resulted in a detailed architecture with all different elements present

New diagnostic and treatment strategies in renal artery stenosis: a promising pursuit or disappointment foretold?

Clinical management of renal artery stenosis has seen a major shift, after randomised clinical trials have shown no group benefit of endovascular intervention relative to optimal medical control. However, the inclusion criteria of these trials have been criticised for focusing on a subset of patients with atherosclerotic renal artery stenosis where intervention was unlikely to be beneficial. Moreover, new imaging and computational techniques have become available, which have the potential to improve identification of patients that will respond to interventional treatment. This review addresses the challenges associated with clinical decision making in patients with renal artery stenosis. Opportunities for novel diagnostic techniques to improve patient selection are discussed, along with ongoing Dutch studies and network initiatives that investigate these strategies

PReS-FINAL-2148: Rheumates@work a cognitive behavioural internet based intervention promoting physical activity in children with juvenile idiopathic arthritis: Preliminary results of a randomized clinical trail

Introduction: Juvenile Idiopathic Arthritis (JIA) is a chronic disease in which periods of active inflammation alternate with periods of inactive disease in an unpredictable way. Although impairments are most pronounced in children with disease activity, deficits like fatigue, decreased physical activity, low aerobic and anaerobic exercise remain impaired long after disease control is obtained. Exercise and physical activity (PA) can be seen as a type of behaviour. Therefore we expect that cognitive behavioural therapy (CBT) could be a successful approach to improve exercise capacity and PA levels in children with JIA. To increase PA levels in children with JIA an internet-based program has been developed. A pilot showed to be effective in improving PA and exercise capacity in children with JIA. Objectives: The aim of this multicenter study is to explore the efficacy of an internet based cognitive behavioural intervention Rheumates@work on PA and exercise capacity. Methods: We performed a randomized controlled trial. Patients with JIA aged 8-12 year, with access to internet were selected for this study. PA was measured with a 7-day activity diary and an Actical accelerometer. PA level was categorized by time spend on moderate to vigorous PA and the number of days with 1 hour of moderate to vigorous PA. Aerobic exercise capacity was assessed by the Bruce treadmill test expressed by walking time. Disease activity was assessed by using the JIA core set. Adherence was electronically monitored. Patients with low physical activity defined as equal to or less than three days of one hour of moderate to vigorous PA or with a low exercise capacity defined as less than P5 on the Bruce treadmill test were included. Results: Out of 83 selected patients, 49 eligible patients were included and randomized in the intervention (n = 28) and control waiting list group (n = 21). Adherence was good 26 out of 28 patients (93%) completed the program. The intervention group improved significantly in exercise capacity (p.01), and in number of minutes spend on vigorous activity (p.00). The control group did not improve significant. Disease activity did not increase in both groups. Conclusion: Preliminary results show that the internet based cognitive behavioural program rheumates@work was effective in improving exercise capacity and stimulated the patients to be more vigorously active. Rheumates@work is safe to administer

Adaptive Shared Control of a Brain-Actuated Simulated Wheelchair

The use of shared control techniques has a profound impact on the performance of a robotic assistant controlled by human brain signals. However, this shared control usually provides assistance to the user in a constant and identical manner each time. Creating an adaptive level of assistance, thereby complementing the user's capabilities at any moment, would be more appropriate. The better the user can do by himself, the less assistance he receives from the shared control system; and vice versa. In order to do this, we need to be able to detect when and in what way the user needs assistance. An appropriate assisting behaviour would then be activated for the time the user requires help, thereby adapting the level of assistance to the specific situation. This paper presents such a system, helping a brain-computer interface (BCI) subject perform goal-directed navigation of a simulated wheelchair in an adaptive manner. Whenever the subject has more difficulties in driving the wheelchair, more assistance will be given. Experimental results of two subjects show that this adaptive shared control increases the task performance. Also, it shows that a subject with a lower BCI performance has more need for extra assistance in difficult situations, such as manoeuvring in a narrow corridor

The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise

Purpose: Peroxiredoxin-2 (PRDX-2) is an antioxidant and chaperone-like protein critical for cell function. This study examined whether the levels of lymphocyte PRDX-2 are altered over one month following ultra-endurance exercise. Methods: Nine middle-aged men undertook a single-stage, multi-day 233 km (145 mile) ultra-endurance running race. Blood was collected immediately before (PRE), upon completion/retirement (POST), and following the race at DAY 1, DAY 7 and DAY 28. Lymphocyte lysates were examined for PRDX-2 by reducing SDS-PAGE and western blotting. In a sub-group of men who completed the race (n = 4) PRDX-2 oligomeric state (indicative of redox status) was investigated. Results: Ultra-endurance exercise caused significant changes in lymphocyte PRDX-2 (F (4,32) 3.409, p=0.020, ?(2) =0.299): seven-days after the race, PRDX-2 levels in lymphocytes had fallen to 30% of pre-race values (p=0.013) and returned to near-normal levels at DAY 28. Non-reducing gels demonstrated that dimeric PRDX-2 (intracellular reduced PRDX-2 monomers) was increased in 3 of 4 race completers immediately post-race, indicative of an "antioxidant response". Moreover, monomeric PRDX-2 was also increased immediately post-race in 2 of 4 race-completing subjects, indicative of oxidative damage, which was not detectable by DAY 7. Conclusions: Lymphocyte PRDX-2 was decreased below normal levels 7 days after ultra-endurance exercise. Excessive accumulation of reactive oxygen species induced by ultra-endurance exercise may underlie depletion of lymphocyte PRDX-2 by triggering its turnover after oxidation. Low levels of lymphocyte PRDX-2 could influence cell function and might, in part, explain reports of dysregulated immunity following ultra-endurance exercise

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression

Background: The aim of this study is to seek an association between markers of metastatic potential, drug resistance-related protein and monocarboxylate transporters in prostate cancer (CaP). Methods: We evaluated the expression of invasive markers (CD147, CD44v3-10), drug-resistance protein (MDR1) and monocarboxylate transporters (MCT1 and MCT4) in CaP metastatic cell lines and CaP tissue microarrays (n=140) by immunostaining. The co-expression of CD147 and CD44v3-10 with that of MDR1, MCT1 and MCT4 in CaP cell lines was evaluated using confocal microscopy. The relationship between the expression of CD147 and CD44v3-10 and the sensitivity (IC50) to docetaxel in CaP cell lines was assessed using MTT assay. The relationship between expression of CD44v3-10, MDR1 and MCT4 and various clinicopathological CaP progression parameters was examined. Results: CD147 and CD44v3-10 were co-expressed with MDR1, MCT1 and MCT4 in primary and metastatic CaP cells. Both CD147 and CD44v3-10 expression levels were inversely related to docetaxel sensitivity (IC50) in metastatic CaP cell lines. Overexpression of CD44v3-10, MDR1 and MCT4 was found in most primary CaP tissues, and was significantly associated with CaP progression. Conclusions: Our results suggest that the overexpression of CD147, CD44v3-10, MDR1 and MCT4 is associated with CaP progression. Expression of both CD147 and CD44v3-10 is correlated with drug resistance during CaP metastasis and could be a useful potential therapeutic target in advanced disease